PReS-FINAL-2281: The incidence of antiphospholipid antibodies in children with juvenile onset lupus erythematosus treated in Department of Pediatric Rheumatology, Institute of Rheumatology, Warsaw in the years 2002-2012

Objectives In 20 patients (37%) high level of IgG anticardiolipin antibodies was discovered. High level of anticardiolipin antybodies IgM was discovered in 6 patients (11.1%). Lupus anticoagulant was determinated in 51 cases, in 17 was positive (31%). 8 patients had the tests for anti beta2GPI carried out and in 4 cases it was positive. In the group of 54 patients 22 (41%) presented prolonged activated partial thromboplastin time (aPTT). Thrombosis and thus antiphospholipid syndrome was confirmed only in 1 case, it was thrombosis of popliteal vein. In 8 children the presence of two different antiphospholipid antibodies and prolonged aPTT were found with at least two hospitalizations. These children didn’t have the symptoms of thrombosis during the time of observation (average 3.5 years) Immunological APS. In the last 10 years in our department were hospitalized also 2 children with antiphospholipid syndrome, they were diagnosed with Lupus-like disease. In the first case there was thrombosis of common femoral vein and deep femoral vein, the additional risk factor could be Legionella pneumophila pneumonia. The other child developed thrombosis of common iliac and external iliac vein, additionaly deficiency of XII factor was discovered. Among our Immunological APS patients there is also the girl with Libmann-Sachs endocarditis in the course of SLE, with aPTT, presence of lupus anticoagulant and anticardiolipin antibodies.